What Research Says About Piacio®

This study explored whether pistachio extract can enhance melatonin’s effects on sleep-related receptors. Researchers tested 25 plant extracts known for calming or sleep-supporting properties. They wanted to find out if any plants could boost melatonin activity.

Using lab-grown cells with human MT1 and MT2 receptors, the researchers exposed these cells to different plant extracts. They then measured how each extract influenced melatonin’s ability to signal through the receptors.

Key findings from the study includes:

1.Pistachio Extract Packs Melatonin

• The pistachio extract delivered a high melatonin content—about 5.3 mg per gram of extract.

2. Pistachio Extract Amplifies Melatonin’s Effects

• When combined, pistachio extract strengthened melatonin’s signals through MT1 and MT2 receptors.

3.Activates Beneficial Pathways

• Pistachio extract boosted helpful pathways by lowering cAMP levels and activating ERK1/2 proteins. These pathways support sleep and cell health.

4. Test Confirmed the Effects

• Researchers used binding tests to check melatonin’s attachment to receptors. Other than cAMP tests and ERK1/2 activation tests showing positive results, β-arrestin2 tests also ensured pistachio extract did not activate undesired signaling.

Overall, Piacio® demonstrated a unique ability to support restful sleep and enhance stress resilience naturally. By combining melatonin and tannins, it offers a non-habit-forming alternative to common sleep aids. Furthermore, individuals who used Piacio® experienced better sleep, improved mood, and greater overall well-being. Consequently, these results highlight Piacio® as a gentle yet effective choice for adults seeking to manage stress and enjoy restorative sleep without synthetic ingredients or sedating effects.

Why This Matters:

Ultimately, understanding the science behind sleep solutions is essential for making informed choices. While many products on the market promise better sleep, few have real data to support their claims. This clinical study sets Piacio® apart by showing clear, measurable benefits through standardized tools.

Additionally, the research confirms that Piacio® can improve sleep quality and reduce stress without causing unwanted side effects. By relying on this study design, it ensures objective and unbiased results. Therefore, this level of evidence gives confidence to adults seeking a natural option to support restful nights and better stress resilience.

Reference:

Lacoste, A. et al. (2023). Pistacia vera extract potentiates the effect of melatonin on human melatonin MT1 and MT2 receptors with functional selectivity. Read the study on PMC